Synthesis of Propargylamine derivatives of benzo[d]oxazole-2-thiol/oxazolo[4,5-b]pyridine-2-thiol as Antimicrobial agents

  • Pankaj B. Gour Dr. Ira Nimdeokar P.G. and Research Centre for Chemistry, Hislop College, Civil Line, Nagpur 440001, India
  • D.P. Rajani bMicrocare laboratory, Surat, Gujarat, India
  • Lata Deshmukh cDr. Ira Nimdeokar P.G. and Research Centre for Chemistry, Hislop College, Civil Line, Nagpur 440001, India
Keywords: Mannich bases, Propagylamine derivatives, Benzo[d]oxazole-2-thiol, oxazolo[4,5-b]pyridine-2-thiol,antibacterial activity, antifungal activity.

Abstract

A new series of propargylamine derivatives of mercaptobenzoxazole and oxazolo[4,5-b]pyridine-2-thiol derivatives 7a-7h were synthesized and evaluated for their antimicrobial activity. The synthesis of propargylamine derivatives has been achieved by the sequential reaction of 2-aminophenol/2-aminopyridin-3-ol with CS2, followed by alkylation and further reaction with secondary amines and formaldehyde undergoes a Mannich reaction at room temperature in the presence of CuI to afforded propargylamine derivatives. All the synthesized compounds were evaluated for their antimicrobial activity viz. E. coli, P. Aeruginosa, S. Aureus and S. Pyogenus and three pathogenic fungi viz. C. Albicans, A. niger and A. Clavatus and promising compounds were identified.

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Published
2018-05-29
Section
Articles