A semi-quantitative approach for understanding role of quorum sensing in bacterial growth



Quorum sensing occurs at high cell density in many micro-organisms. It regulates specialized processes such as genetic competence, bioluminescence, virulence and sporulation. Quorum-sensing is used by many organisms as a mean of communication. This is used to modulate their behaviour as a colony thus ensuring continued survival and future propagation of the colony. Nutrient depletion in a growing bacterial culture has been known to be a major factor in governing bacterial growth and thus a reason for entry of bacterial into the stationary phase. Our studies however attempts to show that nutrient depletion alone is not sufficient to explain entry of the bacterial culture into stationary phase. Our studies suggest that quorum sensing plays a more central role in the physiology of bacteria where quorum-sensing pathways converge with starvation to regulate cell entry into stationary phase.