Synthesis of polyhydroquinolines catalyzed by Ni substituted HPA

  • Amit R Supale A methodology for synthesis of polyhydroquinolines by mixing aldehydes, dimedone, ammonium acetate and ethyl acetoacetate using Ni-HPA catalyst is reported. The reaction was meted out in ethyl alcoholat ambient temperature. The method gave good yields of products in short reaction time compared with previous methods. This methodology offers significant improvements for the synthesis of polyhydroquinolines.
Keywords: Polyhydroquinoline derivatives, Hantzsch reaction, Multicomponent reaction.

Abstract

A methodology for synthesis of polyhydroquinolines by mixing aldehydes, dimedone, ammonium acetate and ethyl acetoacetate using Ni-HPA catalyst is reported. The reaction was meted out in ethyl alcohol at ambient temperature.  The method gave good yields of products in short reaction time compared with previous methods. This methodology offers significant improvements for the synthesis of polyhydroquinolines.

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Published
2019-04-27
Section
Articles