Hepato protective activity of haridra (curcuma longa linn.) In ethanol induced hepatotoxicity in animal model with concomitant ethanol administration
Excessive consumption of alcohol is one of the most important preventable causes of death and associated with non communicable disease (NCD) directly or indirectly as per WHO. Excessive ethanol consumption causes both whole-body and tissue-specific damage and its menace is a major health burden on society. Rehabilitation is still unable to check re-addiction. In this context present article reports the hepatoprotective effect of Haridra in ethanol induced hepatotoxicity with concomitant use of ethanol.
AIM: To evaluate Hepatoprotective effect of Haridra (Curcuma longa Linn.) in Ethanol induced Hepatotoxicity in animal model with concomitant ethanol administration.
30 wistar albino rats of 150-200 grams were randomly allotted in 5 groups. Group I was treated with distilled water. In group II to V ethanol (2ml/200gm bw po) was given till day 59. Group III, IV and V, received Haridra kwath at 3 dose levels of along with ethanol concomitantly from day 29 to day 58. Liver biochemical markers (SGOT,SGPT,ALP,T.BILIRUBIN and T.PROTEIN ) were assessed on day 1, 29, 45 and 59 along with liver histology.
Non- significant reduction in serum levels of SGOT, SGPT and ALP was observed in Haridra kwath treated ethanol intoxicated rats. In histology, sinusoidal congestion in ethanol treated animals whereas normal liver histology was observed in control and Haridra treated animals.
It may be concluded that Haridra posses hepatoprotective effect on concomitant use of alcohol. Clinical trial is needed for further confirmation.
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